Antitumor activity of PBI-1737 in xenograft human prostate PC-3 cancer by inhibition of cell adhesion and migration

1167 Cell adhesion, proteolytic degradation of extracellular matrix and cell migration are interrelated processes responsible for the invasion and metastasis of cancer. In prostate cancer, androgen-independence and bone metastasis are lethal complications in patients. PBI-1737 is a low molecular weight, orally active molecule that inhibits invasion and adhesion of androgen-independent human PC-3 cells. PBI-1737 demonstrated an inhibition of the EGF-induced PC-3 invasion in a two-dimension cell mobility assay. Furthermore, the addition of different concentrations of PBI-1737 induces in a dose dependent manner an inhibition of PC-3 cells adhesion to laminin, matrigel and collagen. The antitumor efficacy of oral administration of PBI-1737 with or without combination of cyclophosphamide on xenograft human prostate PC-3 tumor was also studied. Oral administration of PBI-1737 (50 mg/kg) induces a significant (p