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François Sarra-Bournet

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Anti-Inflammatory/Anti-Fibrotic Compound PBI-4425 Alleviates Bleomycin- and TGF-ß1-Induced Pulmonary Fibrosis

2020
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PS-134-Oral treatment with PBI-4547 promotes beta-oxidation and energy expenditure, and reverses liver damage and white adipose tissue fibrosis in high-fat diet and ob/ob mouse models of NAFLD.

2019 Journal of Hepatology
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THU-078-PBI-4050 inhibits hepatic stellate cell activation, restores autophagy, and reduces CCl4-induced liver fibrosis

2019 Journal of Hepatology
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PBI-4547 Reverses Diabetes and Metabolic Syndrome through Regulation of Lipid/Glucose Metabolism, ß-Oxidation and Fibrosis in Liver, and White Adipose Tissue in ob/ob Mice

2018 Diabetes
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PBI-4547 Improves Glucose Metabolism and Insulin Resistance, and Reduces Liver Damage in a High-Fat Diet Mouse Model of Obesity and Metabolic Syndrome

2018 Diabetes
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Design and Synthesis of New 1,3,5‐Trisubstituted Triazines for the Treatment of Cancer and Inflammation

2018 ChemistryOpen
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PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway

2018 Journal of Pharmacology and Experimental Therapeutics
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PBI-4547 decreases hepatic stellate cell activation via AMPK signaling pathway, and reduces fibrosis in carbon tetrachloride (CCL4)-induced hepatic fibrosis model

2018 Journal of Hepatology
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A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84

2018 American Journal of Pathology
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PBI-4547 Prevents Progression of Prediabetic Condition to Type 1 Diabetes in NOD Mice

2018 Diabetes
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