Cortisone metabolism in liver. II. Isolation of certain cortisone metabolites

Abstract 1. 1. A method of systematic analysis by paper chromatography of metabolites formed during cortisone perfusion through rat livers is presented. 2. 2. The isolation of allopregnan-3α, 17α,21-triol-11,20-dione, allopregnan-3β, 17α,21-triol-11,20-dione, allopregnan-3α, 11β,17α,21-tetrol-20-one, allopregnan-3β, 11β,17α, 21-tetrol-20-one, Δ 4 -pregnen-11β,17α,21-triol-3,20-dione, Δ 4 -pregnen-17α,20β,21-triol-3, 11-dione, and adrenosterone from cortisone perfusates is described. 3. 3. The relationship of these findings to an understanding of pathways of corticosteroid metabolism in liver is briefly discussed.