Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.

Yuequan Shen,Andrzej Joachimiak,Marsha Rich Rosner,Wei-Jen Tang

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.

2006

Yuequan Shen
Andrzej Joachimiak
Marsha Rich Rosner
Wei-Jen Tang

The crystal structure of insulin-degrading enzyme (IDE) in complex with four substrates is presented, revealing the molecular basis for substrate recognition by IDE.

Keywords:

Substrate (chemistry)
Enzyme
Insulysin
Insulin-degrading enzyme
Peptide sequence
Crystal structure
Hydrolase
Biology
Biochemistry
Conformational change
Allosteric regulation
Amylin
Peptide

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