Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.
2012
Abstract The serine/threonine specific protein kinase B-Raf is part of the MAPK pathway and is an interesting oncology target. We have identified thieno[2,3- d ]pyrimidines as a core scaffold of small molecule B-Raf inhibitors. The SAR of analogs in this series will be described.
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