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6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators
2011
A series of 6-aryl-3-pyrrolidinylpyridine analogs was explored as structurally novel negative allosteric modulators of the mGlu5 receptor lacking an alkyne or oxadiazole moiety. Compounds in this series were characterized by tractable SAR, good in vitro potencies and brain penetration in rodents.
Keywords:
- Class C GPCR
- Metabotropic glutamate receptor 3
- Metabotropic glutamate receptor 2
- Metabotropic glutamate receptor 4
- Metabotropic glutamate receptor 5
- Allosteric regulation
- Biochemistry
- Metabotropic glutamate receptor 1
- Chemistry
- Metabotropic glutamate receptor 8
- Oxadiazole
- G protein-coupled receptor
- Moiety
- Stereochemistry
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