Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation
2012
Platelet-reach plasma (PRP) is an attractive tool in regenerative medicine
due to its ability to stimulate proliferation and differentiation of stem
cells. Since dental pulp derived stem cells are recognized as central in
apexogenesis, the aim of the study was to evaluate radiologically and
histologically effects of PRP on apexogenesis in teeth with immature roots.
The study included eight monkeys (Cercopithecus Aethiops) divided in two
equal groups for evaluation 3 and 12 months after treatment. All participants
obtained the same treatment including pulpotomy and after-treatment with:
hydroxiapatite (HA)-incisor and HA+canine PRP. Radiological evaluation was
performed using the long cone paralleling technique for recording of defined
parameters and histological evaluation was performed using tissue removed en
block for the observation of parameters related to apexogenesis. The results
obtained radiologically and histologically have shown increase in bridge
formation in HA+PRP (75%) group after 3 months comparing to HA group (50%).
Contrary to that, after 12 months there were no significant differences
between groups. The root delay was not registered in the HA+PRP group
contrary to HA group where it was registered in 25% after 12 months. Results
of the study suggest that PRP is a powerful tool for intensive and rapid
apexogenesis since it offers clear and comprehensive results (mostly in the
first three months) which are early radiologically visible without any
failure in the proposed requests.
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