Abstract 16269: Targeted Deletion of Thioredoxin-Interacting Protein (Txnip) Enhances Anaerobic Metabolism and Mitochondrial Thioredoxin Activity and Protects the Heart from Ischemia Reperfusion Injury

Jun Yoshioka,William A. Chutkow,Jie Yan,Rong Tian,Jae Bum Kim,Christine E. Seidman,J. G. Seidman,Richard T. Lee

Abstract 16269: Targeted Deletion of Thioredoxin-Interacting Protein (Txnip) Enhances Anaerobic Metabolism and Mitochondrial Thioredoxin Activity and Protects the Heart from Ischemia Reperfusion Injury

2010

Jun Yoshioka
William A. Chutkow
Jie Yan
Rong Tian
Jae Bum Kim
Christine E. Seidman
J. G. Seidman
Richard T. Lee

Thioredoxin-Interacting Protein (Txnip) is a regulator of metabolism and an inhibitor of the antioxidant thioredoxin, but little is known about roles of Txnip in the myocardium. We previously showe...

Keywords:

Ischemia
Thioredoxin-Interacting Protein
Internal medicine
Thioredoxin activity
Anaerobic exercise
TXNIP
Cardiology
Diabetes mellitus
Reperfusion injury
Pharmacology
Medicine
Biochemistry
Antioxidant
Mitochondrion
Cell biology
Regulator
Thioredoxin

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