Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma

Noriko Shimasaki,Tetsuya Mori,Chiharu Torii,Reiko Sato,Hiroyuki Shimada,Yusuke Tanigawara,Kenjiro Kosaki,Takao Takahashi

Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma

2008

Noriko Shimasaki
Tetsuya Mori
Chiharu Torii
Reiko Sato
Hiroyuki Shimada
Yusuke Tanigawara
Kenjiro Kosaki
Takao Takahashi

We investigated preliminarily whether methylenetetrahydrofolate reductase (MTHFR) 677C/T or reduced folate carrier 1 (RFC1) 80G/A polymorphisms were associated with toxicities during maintenance chemotherapy with mercaptopurine (6MP) and methotrexate (MTX) in children with acute lymphoblastic leukem

Keywords:

Pathology
Methylenetetrahydrofolate reductase
Oncology
Lymphoma
Diabetes mellitus
Polymorphism (computer science)
Mercaptopurine
Chemotherapy
Cancer research
Methotrexate
Medicine
Childhood Acute Lymphoblastic Leukemia
Internal medicine
RFC1

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