RFC1

2EBU, 2K6G, 2K7F598119687ENSG00000035928ENSMUSG00000029191P35251P35601NM_001204747NM_002913NM_001363495NM_001363496NM_011258NM_001347357NM_001347358NP_001191676NP_002904NP_001350424NP_001350425NP_001334286NP_001334287NP_035388Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene. Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene. The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability. RFC1 has been shown to interact with: