polymeric microspheres as adjuvants in the production of vaccines against parasites escuticociliados fish.

polymeric microspheres as adjuvants in the production of vaccines against parasites escuticociliados fish. The invention describes the use of microspheres as adjuvants in obtaining a vaccine against Scuticociliatosis. The invention provides a vaccine containing spherical chitosan microspheres and a copolymer of methyl vinyl ether and maleic anhydride, which act as an adjuvant, being coated microspheres membrane antigen of a pathogenic parasite turbot, escuticociliado The vaccine is able to induce potent immune responses and a high protection in turbot against Scuticociliatosis, when administered parenterally, improve the protection induced by vaccines that use oil adjuvants containing metabolizable oils, but without producing undesirable side effects in fishes.