6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D4 receptors

Abstract A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane ( 2d ) had high affinity and selectivity for the D 4 dopamine receptor subtype and was identified as a D 4 antagonist via its attenuation of dopamine-induced GTPγ 35 S binding at the D 4 receptor.