PHYTOCHEMICAL AND PHARMACOLOGICAL RESEARCH ON SOME EXTRACTS OBTAINED FROM SERPYLLI HERBA

A 1:10 tincture and an 1:2 hydro-alcoholic fluid extract were obtained from the vegetal product Serpylli herba originating from the spontaneous species Thymus pulegioides L. The active principles identified in the two extracts by thin layer chromatography were: luteolin, apigenin, caffeic acid, rosmarinic acid, triterpenic acids. The tincture had a content (m/m, g %) of 0.024 - 0.027 flavonoids (expressed as rutin) and 0.336 - 0.356 polyphenolic acids (expressed as clorogenic acid), while the fluid extract had a content (m/m, g %) of 0.104 - 0.142 flavonoids (expressed as rutin) and 1.78 1.84 polyphenolic acids (expressed as clorogenic acid). Both extracts presented an anti-inflammatory effect demonstrated by the plethysmometric technique (rat paw edema induced by kaolin 10 %), effect more intense for the tincture, compared to the control substance (diclofenac) 4 hours after the administration and to the fluid extract. Rezumat