Expressions of discoidin domain receptor 1 and matrix metalloproteinase 2 in salivary gland adenoid cystic carcinoma and clinical significance

PURPOSE: To investigate the expressions of discoidin domain receptor 1(DDR1) and matrix metalloproteinase 2(MMP2) in salivary gland adenoid cystic carcinoma (SACC) and discuss their significance and correlations with clinicopathological parameters. METHODS: SP immunohistochemical method was used to detect the expressions of DDR1 and MMP2 in 54 samples of SACC and 30 normal salivary gland samples. SPSS 13.0 software package was used for statistical analysis. RESULTS: The positive expression rate of DDR1 in SACC was 87.0%, which was significantly higher than that in normal salivary gland tissues (10.0%, P<0.01). The positive expression of DDR1 was related with neural invasion and lymph node metastasis (P<0.05). The positive expression rate of MMP2 was 68.5% in SACC, which was significantly higher than that in normal group(13.3%, P<0.01). The expression of DDR1 was positively correlated with MMP2 by Spearman rank analysis(r=0.332, P<0.05). CONCLUSIONS: High expressions of DDR1 and MMP2 correlate with carcinogenesis and progress of SACC. Supported by Research Fund of Science and Technology Project of Liaoning Province (2012225100).