Formulation and evaluation of simvastatin buccal adhesive tablets

Revathy Krishnan,T.N.K. Suriyaprakash,Sheron Joseph

Formulation and evaluation of simvastatin buccal adhesive tablets

2014

Revathy Krishnan
T.N.K. Suriyaprakash
Sheron Joseph

The objective of the study was to develop buccal adhesive tablets of Simvastatin using mucoadhesive polymers. Simvastatin has short biological half-life (3hr), high first-pass metabolism and poor oral bioavailability..

Keywords:

Organic chemistry
Buccal administration
Simvastatin
Adhesive
Guar gum
Chitosan
Pharmacology
Bioavailability
Xanthan gum
Materials science
Bioadhesive
Drug delivery
Biomedical engineering
Friability
Chromatography

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