SAT0080 Early Rheumatoid Arthritis Patients without Treatment: Baseline Asessment of Insulin Resistance and Cytokines

Objectives To analyze insulin resistance (IR), inflammatory cytokines, adipokines and clinical and laboratory characteristics in patients with early rheumatoid arthritis (ERA) who have not received any treatment for their disease. Methods This is a cross-sectional study based on cases and controls. Forty six consecutively adults (age ≥16 years old) with ERA (disease duration Results 103 subjects were investigated. 12 were excluded (6 were other types of arthritis, 6 were Diabetics) and finally, 91 subjects were included in the study; 46 were patients with RA and 45 were healthy controls. Most of them were women (76.1% in RA). Cases and controls were similar in age, sex and BMI. Regarding characteristics of patients with RA, the mean time duration of RA was 5,9 (SD± 3,5) months, and more than 70% of patients had positive RF and/or AntiCCP. CRP and ESR were higher in RA patients than in controls (p Conclusions The patients with untreated very early RA still do not show insulin resistant observed in patients with established RA despite having high levels of DAS28, CRP, ESR, IL6, TNF-alpha, and resistin. Lack of association between AR and IR indexes might be due to the short course of the disease Disclosure of Interest None Declared