In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.

Peter S. Gargalovic,Pancras C. Wong,Joelle M. Onorato,Heather Finlay,Tao Wang,Mujing Yan,Earl J. Crain,Stéphane St-Onge,Madeleine Héroux,Michel Bouvier,Carrie Xu,Xue-Qing Chen,Claudia Generaux,Michael R. Lawrence,Ruth R. Wexler,David A. Gordon

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.

2021

Peter S. Gargalovic
Pancras C. Wong
Joelle M. Onorato
Heather Finlay
Tao Wang
Mujing Yan
Earl J. Crain
Stéphane St-Onge
Madeleine Héroux
Michel Bouvier
Carrie Xu
Xue-Qing Chen
Claudia Generaux
Michael R. Lawrence
Ruth R. Wexler
David A. Gordon

Background: New heart failure therapies that safely augment cardiac contractility and output are needed. Previous apelin peptide studies have highlighted the potential for APJ (apelin receptor) ago...

Keywords:

In vivo
Apelin receptor
Pharmacology
In vitro
Agonist
Heart failure
Medicine
Contractility
Signal transduction
Apelin

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