Hydrolysis of Surfactant Phospholipids Catalyzed by Phospholipase A2 and Eosinophil Lysophospholipases Causes Surfactant Dysfunction: A Mechanism for Small Airway Closure in Asthma

asthma is proportional to dose and is improved by formu-lation with a new propellant. J Allergy Clin Immunol 1999;104:1215–122233 Vanden Burgt JA, Busse WW, Martin RJ, et al. Efficacyand safety overview of a new inhaled corticosteroid, QVAR(hydrofluoroalkane-beclomethasone extrafine inhalationaerosol), in asthma. J Allergy Clin Immunol 2000; 106:1209–122634 Lipworth BJ. The comparative safety/efficacy ratio of HFA-BDP. Respir Med 2000; 94(suppl):S21–S2635 Cohen R, Fireman P, Windom H. Long-term safety ofbeclomethasone dipropionate extrafine aerosol (HFA-BDP)[abstract]. Am J Respir Crit Care Med 1999; 159:A63136 Thompson PJ, Davies RJ, Young WF, et al. Safety of hy-drofluoroalkane-134a beclomethasone dipropionate extrafineaerosol. Respir Med 1998; 92:33–39