Synthesis of dibenzo[a,d]cycloheptanes as cytokine biosynthesis inhibitors

Abstract 2-[10,11-Dihydro-5-ethoxy-5 H -dibenzo[a,d]cyclohepten-5-yl]-N,N-dimethyl-ethanamine ( 1 ) has been found to possess anticytokine activity. The synthesis and structure-activity relationship study of a series of analogues are reported.