1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists.
2001
Abstract A series of 1,4-benzodiazepines, N -1-substituted with an N -isopropyl- N -phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In vitro agonist activity on isolated guinea pig gallbladder along with in vivo induction of satiety following intraperitoneal administration in a rat feeding assay was demonstrated.
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