Imerslund-Gr€asbeck syndromewith developmental cataract
2017
An 18-year-old girl was referred to the ophthalmology department
with diminution of vision in both eyes of 1-year duration.
Imerslund-Gr€asbeck syndrome was diagnosed. On examination,
anterior polar cataract and posterior subcapsular opacification
were present in the right eye and posterior subcapsular
opacification was present in the left eye. The rest of the anterior
segment was unremarkable in both eyes. Congenital and other
systemic associations were ruled out for the lenticular opacity.
In the Imerslund-Gr€asbeck syndrome, cobalamin deficiency is
associated with proteinuria. Low vitamin B12 levels result in
high plasma homocysteine levels, which is a potential biomarker of
oxidative damage and cataractogenic stressor. Screening and
regular follow-up of these cases can result in early detection of
cataract and improvement of the visual acuity.
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