SCANNING ION MICROBEAM ANALYSIS OF DIFFUSION IN IN-MOUTH DRUG RELEASE POLYMERS

With the aim of characterizing polymer-based drug delivery systems a combination of Scanning MeV 3He microbeam Nuclear Reaction, Backscattering and Particle Induced X-ray Emission (PIXE) techniques has been developed. This, together with gravimetric and UV techniques has been applied to characterize both water infusion and drug effusion for three in-mouth polymer–drug systems. Preliminary results are presented from the exposure of polymers, containing drug at a level of 9% by weight of the dry polymer, to both pure water and a phosphate buffered saline solution at 37°C.