COMPLEMENT ACTIVATION BY CLUMPING FACTOR AND PROTEIN A FROM STAPHYLOCOCCUS AUREUS STRAIN E 2371
2009
Purified surface components from Staphylococcus aureus strain E 2371, which bind to human plasma proteins, were tested for their ability in vitro to activate complement present in normal human serum. Staphylococcal clumping factor as well as protein A both isolated from strain E 2371 were capable of activate complement, while the fibronectin-binding protein showed no activity. At identical molar concentrations clumping factor was more potent than protein A to induce complement consumption. Both clumping factor and protein A were able to activate the alternative complement pathway as demonstrated in serum chelated with ethylene-glycerol-tetra-acetic acid (10 mM) in the presence of MgCl2 (10 mM).
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
23
References
8
Citations
NaN
KQI