Modes of division and differentiation of neural stem cells

Abstract Hippocampal neurogenesis presents an unorthodox form of neuronal plasticity and may be relevant for the normal or abnormal functioning of the human and animal brain. As production of new neurons decreases after birth, purposefully activating stem cells to create additional new neurons may augment brain function or slow a disease’s progression. Here, we describe current models of hippocampal stem cell maintenance and differentiation, and emphasize key features of neural stem cells’ turnover that may define hippocampal neurogenesis enhancement attempts’ long-term consequences. We argue that even the basic blueprint of how stem cells are maintained, divide, differentiate, and are eliminated is still contentious, with different models potentially leading to vastly different outcomes in regard to neuronal production and stem cell pool preservation. We propose that to manipulate neurogenesis for a long-term benefit, we must first understand the outline of the neural stem cells’ lifecycle.