Conformationally Restricted 1,5-Diarylpyrazoles are Selective COX-2 Inhibitors.
2010
Abstract Benzothiopyranopyrazoles and benzopyranopyrazoles containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. This new class of COX-2 selective inhibitors possess antiinflammatory activity in vivo.
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