Clinical significance of the triage role of HR-HPV for atypical squamous cells,cannot exclude high-grade squamous intraepithelial lesion

Objective To evaluate the possible role of HR-HPV testing for ASC-H in clinical practice.MethodsAmong 17 125 cervical smesrs in China-Japan friendship hospital from June 2004 to April 2007,those interpreted as ASC and those had HR-HPV testing were enrolled in the study.The possible role of triage of HR-HPV testing for ASC-H was evaluated according to the results of biopsy.Results CIN 2/3 was identified in 25 of 52(48.1%) patients with HR-HPV positive ASC-H compared with 48 of 190(25.2%)patients with HR-HPV positive ASC-US(P0.01).CIN 2/3 was identified on a follow-up in a similarly small proportion of both patients with HR-HPV negative ASC-H and patients with HR-HPV negative ASC-US(5.9%、5.7%,respectively).The sensitivity of HR-HPV testing in detecting CIN 2/3 for ASC-US and ASC-H was 82.8%,96.2%,respectively;and the negative prective rate was 94.3%,92.3%,respectively.Conclusion Patients with ASC-H and negative HR-HPV testing may be more efficiently managed by follow-up with regular Pap and HR-HPV testing rather than universal colposcopy.HR-HPV testing for triage of ASC-H in routine practice may have the same important triage role as for ASC-US.