Hematopoietic stem cell transplantation (HSCT) as an example of personalized approach in the management of individual disease

Hematopoietic stem cells (HSCs) and their transplantation has proved itself as an effective approach to treat different diseases. Since the first 3 cases of successful allo-HCT in 1968, the number of allo-HCTs performed annually has increased steadily over the past 3 decades [1]. From the very beginning HSC demonstrates the importance of individual/personal approach in all steps of the management of the disease. One millionth transplant is celebrated in 2013. Individual treatment plan is unavoidable from the very first days after diagnose. There is necessary to target the cure of the patient. For that purpose right treatment options pretransplant are necessary to choose. Many disease specific transplant regimens are under development to improve transplant outcome after HT. Depending on the disease and patient’s status the source of the HSCs (autologous or allogeneic) will be considered.