나이팜과 키토산을 이용한 온도감응성 약물전달 시스템

New thermosensitive nanoparticles. based on PNIPAAm-AA core and chitosan shell structure, were designed and synthesized for the controlled release of the loaded drug. PNIPAAm nanoparticle containing carboxylic group on their surface was synthesized using emulsion polymerization. The particle size of synthesized nanoparticles was varied from 380 nm to 25 nm as temperature of the dispersed medium increased. LMWSC-conjugated nanoparticles of 2wt% MBA, crosslinking monomer, leaded to a stable aqueous dispersion at concentration of 1mg/1ml otherwise showed gel collapse temperature. The effect of temperature on the dynamic behavior of the PNIPAAm chains were also studied by dynamic light scattering and UV-Vis absorption measurements.