Avaliação clínica do uso de colírios de antiangiogênico

Pathological angiogenesis is the crux of the progression of wet age-related macular degeneration (AMD). To treat this choroidal neovascularization, vascular endothelial growth factor (VEGF) inhibitors (bevacizumab and ranibizumab)1 and VEGF-trap (aflibercept) have been successfully used.2 However, treatment with monthly injections is often required for better management of the pathology, which translates into high costs (financial, length of treatment, and mobilization of family members).3 In this context, various drugs are being tested for AMD. In a previous phase II study with pazopanib eye drops at 5 mg/mL three times a day, an improvement in best-corrected visual acuity (BCVA) was observed in patients with exudative AMD.4 The present multicenter, randomized, double-blinded study aimed to assess the efficacy of the use of pazopanib eye drops as an adjuvant therapy in the treatment of exudative AMD.