Do lowered factor VII levels at extremely high endogenous oestradiol levels protect against thrombin formation

The purpose of the study was to find a model to study the effect of endogenous oestradiol on haemostasis. Hormones and haemostatic variables were therefore measured before and after in vitro fertilization and egg replacement therapy in 14 women with tubal infertility. The differences between the levels of the haemostatic variables at minimum and maximum levels of oestradiol and progesterone were evaluated. A significant increase in the plasma levels of coagulation factor VIII, von Willebrand factor and fibrinogen was found between samples drawn before stimulation and at the highest oestradiol levels (P