Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease

Purpose: To investigate changes in the area of the foveal avascular zone (FAZ) in patients with retinal vascular disease. Patients and methods: This retrospective, consecutive study examined 53 eyes of 53 patients with macular edema due to branch retinal vein occlusion in 25 patients (47.2%) and nonproliferative diabetic retinopathy in 28 patients (52.8%). The macular edema was treated with an intravitreal injection of 0.05 mL equal to 1.25 mg bevacizumab. Before and 6–8 weeks after the injection, best corrected visual acuity, slit lamp biomicroscopy of the anterior segment and fundus, optical coherence tomography, and fluorescein angiography were conducted. The FAZ was manually circumscribed on early-phase angiography images and the area of the FAZ was measured. Results: The preoperative overall mean FAZ area was 0.327 ± 0.126 mm 2 (median 0.310 mm 2 ). ;