Additional data from the NMR investigation of tofizopam

: The seven-membered ring of Tofizopam exists in two stable conformations in solutions. Separately detectable (Et)Me triplets of the conformers offered us a way for quantitative determination of conformer ratios. Temperature dependence of free enthalpy of conformers were calculated from the measured conformer ratios in different temperatures. Entropy component of the free enthalpy proved to be 35% of the whole at 36 degrees C. Half period of attaining equilibrium ratio of conformers was 2 hours at 36 degrees C.