N-Arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B
2003
Abstract To improve the pharmacokinetics of a previously reported series of dipeptidyl nitrile cathepsin B inhibitors, the P 2 –P 3 amide group was replaced with an arylamine. Further optimization of this template resulted in highly potent and selective inhibitors with excellent oral availability.
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