Thia-prostanoid analogs with combined thromboxane receptor antagonist/thromboxane synthase inhibitor activities. Synthesis and pharmacological evaluation

This report describes the incorporation of thia-prostanoid, amino-prostanoid and thromboxane synthase inhibitor features into a new series of thia-prostanoids that combines potent thromboxane receptor antagonist/thromboxane synthase inhibitor activities. Synthesis and biological evaluation is discussed.