Placentation defects are highly prevalent in embryonic lethal mouse mutants

Vicente Pérez-García,Elena Fineberg,Robert Wilson,Alexander Murray,Cecilia Icoresi Mazzeo,Catherine Tudor,Arnold R. Sienerth,Jacqueline K. White,Elizabeth Tuck,Edward Ryder,Diane Gleeson,Emma Siragher,Hannah Wardle-Jones,Nicole Staudt,Neha Wali,John E. Collins,Stefan H. Geyer,Elisabeth M. Busch-Nentwich,Antonella Galli,James C. Smith,Elizabeth J. Robertson,David J. Adams,Wolfgang Weninger,Timothy J. Mohun,Myriam Hemberger

Placentation defects are highly prevalent in embryonic lethal mouse mutants

2018

Analysis of embryonic lethal and sub-viable mouse knockout lines reveals that ablation of many genes affects placental development, and that the occurrence of placental defects is co-associated with abnormal brain, heart and vascular system development.

Keywords:

Genetics
Mutant
Gene
Placentation
Embryonic stem cell
Biology
Cell biology
Embryo
Trophoblast
Gene knockout
Embryogenesis
Stem cell
Placenta

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