Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
2017
Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH differentiation and GC responses potentially via the derepression of Etv5.
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