ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

ORMDL3 has been identified as a gene associated with asthma susceptibility, but its exact role in the pathogenesis of this disease is not well known. Here, the authors propose that induction of ORMDL3 in eosinophils modulates the expression of integrins, which could contribute to a key inflammatory event in asthma.