Intermolecular palladium-catalyzed coupling of 2-halopyridines and alcohols for the preparation of pyridine ether PPAR agonists

A series of pyridine ether PPAR agonists were synthesized through intermolecular palladium-catalyzed coupling of 2-halopyridines and alcohols. This method proved to be versatile, efficient, and amenable to parallel synthesis.