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Paul S. Humphries

Pfizer

31

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373

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Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration

2018 Sleep
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Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents

2017 Bioorganic & Medicinal Chemistry Letters
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Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents.

2016 Bioorganic & Medicinal Chemistry Letters
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Amides, carbamates et urées contenant du carbazole en tant que modulateurs de cryptochrome

2015
- Ross Bersot
- Paul S. Humphries
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Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket.

2014 Bioorganic & Medicinal Chemistry Letters
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Metabolism-guided design of short-acting calcium-sensing receptor antagonists.

2010 ACS Medicinal Chemistry Letters
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Dérivés de l'acide 1,1-(diméthyl-éthylamino)-2-hydroxy-propoxy]-éthyl}-3-méthyl-biphényl-4-carboxylique utiles en tant qu'antagonistes des récepteurs du calcium

2010
- Paul S. Humphries
- David A. Price
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Facile synthesis of 4,5-disubstituted-3(2 H)-pyridazinones

2009 Tetrahedron Letters
- Paul S. Humphries
- Robert M. Oliver
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Chemically-enabled synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones

2009 Tetrahedron Letters
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Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.

2009 Bioorganic & Medicinal Chemistry Letters
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