FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling

In zebrafish embryos, Wnt and Notch signalling have been implicated in the emergence of haematopoietic stem cells during somitogenesis. Here the authors show that FGF signalling via FGFR4 acts downstream of Wnt signalling to regulate the levels of the Notch ligand DeltaC and therefore Notch pathway activity.