PTH(1-34) for Surgical Hypoparathyroidism: A Prospective, Open-Label Investigation of Efficacy and Quality of Life.

Context: Conventional therapy for hypoparathyroidism consists of calcium and calcitriol, but sometimes normal serum calcium cannot be maintained, and/or this approach might lead to nephrocalcinosis, nephrolithiasis, or renal insufficiency. Objective: The objective of the study was to investigate the effects of 6 months of PTH(1–34) treatment in adult subjects with postoperative hypoparathyroidism and to evaluate quality-of-life changes. Design: This was a 2-year prospective, open-label study. At baseline and after 6 months of PTH(1–34) treatment, calcium and vitamin D supplementation requirements, serum calcium, phosphate, creatinine, alkaline phosphatase, uric acid, and 24-hour urinary calcium excretion were evaluated. Quality of life was evaluated by the Rand 36-Item Short Form Health Survey covering eight domains of physical and mental health. Setting: This was an Italian multicentric study. Participants: Participants included 42 subjects with surgical hypoparathyroidism (90% females, age range 34–77 y...