TIRR regulates 53BP1 by masking its histone methyl-lysine binding function

Pascal Drané,Marie Eve Brault,Gaofeng Cui,Khyati Meghani,Shweta Chaubey,Alexandre Detappe,Nishita Parnandi,Yizhou He,Xiao Feng Zheng,Maria Victoria Botuyan,Alkmini Kalousi,William T. Yewdell,Christian Münch,J. Wade Harper,Jayanta Chaudhuri,Evi Soutoglou,Georges Mer,Dipanjan Chowdhury

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function

2017

Pascal Drané
Marie Eve Brault
Gaofeng Cui
Khyati Meghani
Shweta Chaubey
Alexandre Detappe
Nishita Parnandi
Yizhou He
Xiao Feng Zheng
Maria Victoria Botuyan
Alkmini Kalousi
William T. Yewdell
Christian Münch
J. Wade Harper
Jayanta Chaudhuri
Evi Soutoglou
Georges Mer
Dipanjan Chowdhury

A new protein, Tudor interacting repair regulator (TIRR), affects DNA repair by masking the chromatin interaction domain of 53BP1, thereby preventing its recruitment to double-strand breaks.

Keywords:

Chromatin
Masking (art)
Cell biology
Double-Strand DNA Breaks
Lysine
Gene
DNA repair
Histone
Chemistry
Bioinformatics
TUDOR-INTERACTING REPAIR REGULATOR
DNA damage
Poly ADP ribose polymerase
Protein kinase A
Tudor domain
Histone H4

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