Interleukin-10 Delivery via Mesenchymal Stem Cells: A Novel Gene Therapy Approach to Prevent Lung Ischemia–Reperfusion Injury

Ischemia reperfusion (IR)-induced lung injury is a major cause of primary graft failure after lung transplantation. In this study, Manning and colleagues examine whether bone-marrow derived mesenchymal stem cells engineered to secrete IL-10 can prevent lung IR injury in a rat model.