Tetrahydrobiopterin responsiveness in patients with phenylketonuria.
2004
Abstract Objectives: To investigate the BH 4 response in a group of patients with phenylketonuria (PKU) in order to offer this alternative treatment to the responsive patients. Design and methods: The 24-h-long Phe/BH 4 loading test was performed on 64 PKU patients requiring dietary treatment. Results: All patients with mild-PKU and 75% of patients with moderate-PKU were BH 4 responsive, while only 11% of classic-PKU patients showed good/partial response ( P 4 loading test were significantly different in the three PKU phenotypes (mild PKU: 67.9 ± 18.7; moderate PKU: 37.4 ± 16.8; and classical PKU: 21.9 ± 13.7; ANOVA with Bonferroni correction: P 4 responsiveness, all of them combined with mutations with zero predicted residual activity. Conclusion: Both the percentage of Phe decrease and the Phe value achieved 24 h after BH 4 loading are valuable data in predicting a response. We report four mutations not previously associated with BH 4 responsiveness.
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