Enhancement of theophylline clearance by oral activated charcoal

A randomized crossover trial of the effect of oral activated charcoal on the kinetics of intravenous theophylline was carried out in six normal male subjects. After intravenous aminophylline (6 mg/kg), subjects received water or water with activated charcoal (140 gm) in divided doses over 12 hr. Serum theophylline concentrations were measured from 0 to 24 hr after the aminophylline infusion. Treatment with activated charcoal decreased the serum t½ from 6.4 ± 1.2 to 3.3 ± 0.4 (SEM) hr and the serum AUC from 78 ± 14 to 42 ± 4 mg · hr/l. Percent decrease in AUC after treatment with charcoal correlated positively with the endogenous theophylline serum t½ (r = 0.94). These results suggest that oral activated charcoal (1) enhanced the total body clearance of theophylline and (2) may be efficacious in the treatment of theophylline poisoning, especially in patients with prolonged serum t½s of theophylline. Clinical Pharmacology and Therapeutics (1983) 33, 351–354; doi:10.1038/clpt.1983.44