Tough robust dual responsive nanocomposite hydrogel as controlled drug delivery carrier of asprin

Abstract Smart mechanical strong hydrogels have gained increasing attention in the last decade. A novel tough robust biocompatible and dual pH- and temperature- responsive poly (N-isopropylacrylamide)/clay (Laponite XLS)/gold nanoparticles (Au-S-S NPs)/caboxymethyl chitosan (CMCTs) nanocomposite hydrogel was synthesized by a facile one-pot in situ free radical polymerization, using clay and Au-S-S NPs as the cross-linkers instead of toxic organic molecules. By tuning the crucial factors, concentration of Au-S-S NPs, CMCTs and clay, the obtained hydrogels exhibited the highest tensile stress of 535.5 kPa at the breaking deformation of 1579.5%. Furthermore, these synthesized hydrogels were tough enough and simultaneously owned a fast recoverability after unloaded in 15 min at room temperature. Moreover, effects of the above factors on swelling and swelling-shrinking behaviors of the prepared hydrogels were investigated in detail. In addition, these designed hydrogels also possessed a controlled drug release property of asprin by adjusting their inner crosslink density. Owing to this property, they could be used as the potential drug delivery carriers in future.