Themis2 lowers the threshold for B cell activation during positive selection

Daian Cheng,Mukta Deobagkar-Lele,Ekaterina Zvezdova,Seeyoung Choi,Shoji Uehara,Delphine Baup,Sophia Bennett,Katherine R. Bull,Tanya L. Crockford,Helen Ferry,Claude Warzecha,Marlène Marcellin,Anne Gonzalez-de-Peredo,Renaud Lesourne,Consuelo Anzilotti,Paul E. Love,Richard J. Cornall

Themis2 lowers the threshold for B cell activation during positive selection

2017

Daian Cheng
Mukta Deobagkar-Lele
Ekaterina Zvezdova
Seeyoung Choi
Shoji Uehara
Delphine Baup
Sophia Bennett
Katherine R. Bull
Tanya L. Crockford
Helen Ferry
Claude Warzecha
Marlène Marcellin
Anne Gonzalez-de-Peredo
Renaud Lesourne
Consuelo Anzilotti
Paul E. Love
Richard J. Cornall

Cornall and colleagues show that Themis2 interacts with the phospholipase PLC-γ2 and lowers the threshold for B cell activation by low but not high avidity antigens.

Keywords:

Cell biology
Immunology
Humoral immunity
Biology
Antigen
Phospholipase
B-cell activation
High avidity
LYN
Acquired immune system
B-cell receptor
Germinal center
B-1 cell
Negative selection
Cellular differentiation

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