Primary myelofibrosis with concurrent precursor T-cell lymphoblastic lymphoma of the spleen in a 26-year-old patient

Primary myelofibrosis (PMF) is rare myeloproliferative disease usually diagnosed in older patients. Reports of a concurrent acute lymphoblastic leukemia or lymphoma in PMF are rare. We present a case of a 26-year old patient with PMF and precursor T-cell acute lymphoblastic lymphoma of the spleen and lymph nodes. The patient was treated with splenectomy and allogeneic stem cell transplantation (allo-SCT) and remains in remission from both PMF and lymphoblastic lymphoma 6 months after the full strength allo-SCT. To our knowledge this is second report of concurrent PMF and precursor T-cell acute lymphoblastic lymphoma, and first report of a successful treatment for both underlying conditions.