Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

A generalized therapy that targets both arms of the angiogenic process that supplies blood to tumors and drains metastatic cells from them may be achieved by inhibiting production of a critical bioactive lipid mediator, as illustrated in this preclinical breast cancer study.