Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
1999
Abstract The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Optimization of cysteine-substituted diarylethers led to highly potent imidazole-containing diarylethers and diarylsulfones. Polar diaryl linkers dramatically improved potency and gave highly cell active compounds.
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